Geometric Aging of the Thoracic Aorta: Insights From 2 Large Cohorts.

ABSTRACT:

Background

Aortic structural degeneration occurs with aging; however, 3-dimensional geometric remodeling has not been well characterized in large populations.

Methods

We segmented the thoracic aorta from magnetic resonance images of 56 164 UKB (UK Biobank) participants and computed tomography images of 9417 PMBB (Penn Medicine Biobank) participants. We quantified structural measurements of elongation, dilation, tortuosity, and curvature across the thoracic aorta. Multivariate linear regression models estimated the associations between age and aortic structure in a subset of normative healthy participants from the UKB (n=3532), and in the overall cohorts.

Results

Patterns of aging were highly consistent between the UKB and PMBB. In the UKB normative subset, aging was a

SUBMITTER: Beeche CA 

PROVIDER: S-EPMC12560236 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature