Indications for the evaluation and supplementation of hypophosphatemia: an umbrella systematic review of reviews and guidelines.

ABSTRACT:

Background

Hypophosphatemia, defined as low serum phosphate levels, is a frequent yet underrecognized condition associated with significant morbidity. Its etiology ranges from chronic conditions such as osteomalacia to acute states such as refeeding syndrome. This review systematically summarizes evidence and guidelines for phosphate testing and supplementation in adults, aiming to support clinical decision-making.

Methods

We conducted a systematic review following the PRISMA guidelines. Searches of MEDLINE, Embase, the Cochrane Library, and Google Scholar from inception to September 2024 included reviews, guidelines, and consensus statements addressing phosphate measurement for hypophosphatemia and supplementation in adults outside intensive care settings. Eligibility crite

SUBMITTER: Netzer S 

PROVIDER: S-EPMC12560374 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature