Genetic diversity and population structures of Plasmodium falciparum parasites imported to China from Central and West Africa determined using a SNP barcode.

ABSTRACT:

Background

Malaria remains a highly threatening infectious disease, with Africa being the main epidemic area. China has achieved the notable feat of eliminating malaria domestically, yet the looming threat of imported malaria cases remains a concern. This study aims to apply the SNP barcode technology to investigate the population structure of P. falciparum imported to China from Central and West Africa.

Methods

We applied a 24-SNP high-resolution melting (HRM) barcode to analyze the diversity of P. falciparum populations imported to China from Central and West Africa.

Results

A total of 181 samples were analyzed using HRM assay to obtain a complete 24-SNP barcode. There was no significant difference in the proportion of multi-clone infections among the four populatio

SUBMITTER: Zeng W 

PROVIDER: S-EPMC12560413 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature