Long-term BMI trajectories and epigenetic age acceleration: the role of genetic risk for obesity.

ABSTRACT:

Background

Previous studies reported mixed findings in the relationship between body mass index (BMI) and epigenetic age acceleration (EAA), while none considered long-term trajectory of BMI and individuals' genetic background. Therefore, we aimed to evaluate the joint effects of long-term BMI trajectory and genetic risk for obesity on EAA among older US adults.

Methods

We performed secondary analyses of panel survey data from 3312 participants of the Health and Retirement Study. BMI was assessed biennially from 1996 to 2016. Latent variable mixture modeling was used to identify distinct BMI trajectories over the 20-year period. Thirteen epigenetic clocks were used to calculate EAAs based on DNA methylation data from the 2016 Venous Blood Study (VBS). Genetic risk for obesit

SUBMITTER: Wen Y 

PROVIDER: S-EPMC12560447 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature