Simple spectrophotometric methods for the quantitative analysis of two binary mixtures containing paracetamol as a major component.

ABSTRACT: This work demonstrates simple and reliable spectrophotometric methods for the simultaneous determination of paracetamol (PAR) and meloxicam (MEL) in mixture I as well as PAR and domperidone (DOM) in mixture II in bulk form and laboratory-made tablets. Successful determination of mixture I was accomplished using direct zero-order spectrophotometry at 361 nm for MEL and first-order derivative (¹D) spectrophotometry by measuring the peak at 342 nm and the trough at 262 nm for MEL and PAR respectively. On the other hand, a ratio difference method was suggested for the analysis of mixture II. The difference between the ratio spectra amplitudes at 256 and 288 nm were recorded for PAR determination, and 216 and 288 nm for DOM quantitation using 50 µg/mL DOM and PAR respectively as divi

SUBMITTER: Guirguis KM 

PROVIDER: S-EPMC12560461 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature