Peripheral blood mononuclear cell DNA methylation biomarkers for prognostic stratification in Chinese lung adenocarcinoma: a genome-wide epigenetic profiling study.

ABSTRACT:

Background

While DNA methylation profiling from peripheral blood mononuclear cells (PBMCs) has demonstrated utility in cancer risk prediction, notably for non-small cell lung cancer (NSCLC), its prognostic value for survival stratification in Chinese lung adenocarcinoma (LUAD) patients remains unestablished. This study addresses whether PBMC-derived methylation signatures can discriminate clinical outcomes in EGFR-mutation LUAD subgroups.

Methods

We performed genome-wide methylation analysis of PBMCs from LUAD patients using the Infinium Methylation EPIC 850 K array. Clinical characteristics were associated with overall survival (OS) through Cox regression. Prognostic differentially methylated positions (DMPs) were identified via Lasso regression, followed by the constructio

SUBMITTER: Li P 

PROVIDER: S-EPMC12560486 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature