Protocol for a prospective cohort study on pre-eclampsia risk prediction in Ghana, Kenya and South Africa.

ABSTRACT:

Background

Low dose aspirin is recommended for the prevention of pre-eclampsia in high-risk women. As part of the formative work for the "Preventing pre-eclampsia: Evaluating AspiRin Low-dose regimens following risk Screening" (PEARLS) trial, we aim to validate and implement a pre-eclampsia risk-screening algorithm, based on a restricted-variable version of the Fetal Medicine Foundation (FMF) algorithm. In the trial phase, we will compare different daily aspirin doses (75 mg vs. 150 mg) for pre-eclampsia prevention and postpartum bleeding in high-risk women. This study protocol outlines the validation cohort for a restricted variable FMF algorithm in participating facilities in Ghana, Kenya, and South Africa.

Methods

This multi-country, prognostic accuracy study using a pros

SUBMITTER: PEARLS study collaborators 

PROVIDER: S-EPMC12560518 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature