Human induced pluripotent stem cell-derived cardiomyocytes improve recovery from myocardial infarction in non-human primates.

ABSTRACT:

Background

The transplantation of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) represents a promising next-generation cell therapy for repairing injured myocardium. However, the safety, efficacy, and pharmacokinetics of these cells in non-human primates (NHPs) with myocardial infarction (MI) have not been systematically investigated.

Methods

Sixteen rhesus monkeys underwent MI surgery, with 10 monkeys receiving 1 × 10⁸ hiPSC-CMs through intramyocardial injection and six monkeys receiving vehicle alone. Echocardiography and cardiac MRI were performed to evaluate the cardiac function and infarct size. A wearable electrocardiogram monitoring device was used to detect postoperative arrhythmias. The bio-distribution of grafted cells in a separ

SUBMITTER: Guan X 

PROVIDER: S-EPMC12560527 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature