Genetic resilience to chronic obstructive pulmonary disease is a clinically distinct subtype in individuals with cigarette smoke exposure.

ABSTRACT:

Background

There is substantial unexplained variability in the development of disease. A genetic risk score for COPD identifies individuals at markedly elevated risk of COPD; however, many high-genetic risk individuals do not develop disease. We sought to define genetic resilience in COPD by identifying and characterizing individuals who are resistant to their elevated genetic susceptibility.

Methods

We defined resilience to genetic risk (genetic resilience) as absence of airflow obstruction (FEV₁/FVC ≥ 0.70) in individuals with cigarette smoking exposure with a polygenic risk score for COPD at the 90th percentile or above. We defined clinical resilience according to previously published criteria, including a low symptom burden, limited radiographic disease, and n

SUBMITTER: Ghosh AJ 

PROVIDER: S-EPMC12560536 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature