Pre-pandemic disease trajectories and genetic insights into long COVID susceptibility.

ABSTRACT:

Background

Long COVID refers to the persistence of symptoms after SARS-CoV-2 infection. While individual comorbidities have been studied, the role of coexisting chronic conditions remains underexplored. This study investigates whether pre-pandemic disease trajectories-sequential patterns of chronic conditions-modify long COVID risk and symptom profiles and explores shared genetic susceptibility.

Methods

We analysed 8322 adult participants (58.6% women) from the COVICAT cohort (aged 40-65 at recruitment), followed between 2020 and 2023. Disease trajectories were reconstructed from electronic health records (2010-2019), focusing on sequences of two chronic conditions found in ≥ 1% of the cohort. We evaluated shared genetic architecture and polygenic risk scores (PRS) for predi

SUBMITTER: Blay N 

PROVIDER: S-EPMC12560560 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature