Impact of PG-SGA-assessed malnutrition stratification on clinical outcomes in advanced gastrointestinal malignancies: a retrospective cohort study.

ABSTRACT:

Introduction

The traditional TNM staging system fails to explain survival heterogeneity in advanced gastrointestinal cancer, while malnutrition remains an underutilized prognostic modulator. We aimed to establish the prognostic value of dynamic nutritional risk stratification using the Patient-Generated Subjective Global Assessment (PG-SGA).

Methods

In this retrospective cohort study, 102 patients with AJCC 8th edition stage II-IV gastrointestinal malignancies underwent serial PG-SGA assessments at admission and 3-month follow-up. Nutritional risk was stratified as low-risk (PG-SGA 3-8) or high-risk (PG-SGA ≥ 9). Associations with overall survival (OS) were analyzed via Kaplan-Meier curves and multivariable Cox regression.

Results

Among 102 advanced gastrointestinal m

SUBMITTER: Zhuang P 

PROVIDER: S-EPMC12560561 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature