Effect of egg consumption on circulating choline, betaine, and trimethylamine n-oxide in adults: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background and objective

Eggs are rich in choline and other methyl donors that may influence metabolic health, yet their effects on circulating metabolites such as choline, betaine, and trimethylamine N-oxide (TMAO) remain unclear. Understanding these effects is critical due to potential links with cardiometabolic risk. This study aimed to systematically evaluate and quantitatively synthesize the effects of egg consumption on plasma levels of choline, betaine, and TMAO in randomized controlled trials (RCTs), and to explore potential effect modifiers.

Methods

A systematic search of electronic databases was conducted to identify RCTs examining the effects of egg consumption on circulating choline, betaine, and TMAO. Data were pooled using random-effects meta-analyses. Subgroup

SUBMITTER: Aryaeian N 

PROVIDER: S-EPMC12560564 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature