KIAA1429-mediated M⁶A methylation inhibits osteoclast differentiation via stabilizing Lrp4 mRNA and protects against osteoporosis.

ABSTRACT: N⁶-methyladenosine (m⁶A) is a novel epigenetic modification that has been reported to be involved in the progression of osteoporosis (OP), providing new insights into the pathogenesis of OP. The methyltransferases KIAA1429 [also known as virus-like m⁶A methyltransferase-associated protein (VIRMA)] participates in various essential biological processes by regulating target gene expression levels. However, the function of KIAA1429-mediated m⁶A modification in OP progression remains unclear. This study aimed to investigate the biological roles and potential underlying mechanisms of KIAA1429 in OP and osteoclast differentiation. scRNA-seq combined with bulk RNA-seq screening for the differential gene KIAA1429. Analysis of clinical data confirmed KIAA

SUBMITTER: Liu J 

PROVIDER: S-EPMC12560588 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature