Effect of antidiabetic drugs in Alzheimer´s disease: a systematic review of preclinical and clinical studies.

ABSTRACT: The potential neuroprotective effects of antidiabetic treatments have been largely assessed in Alzheimer's disease (AD) and AD-like dementia models, with or without metabolic disorders. In this Line, these effects Have also been addressed in wide population-based studies or in patients with mild cognitive impairment, AD, diabetes or combined pathologies. Most common treatments include glucagon-like peptide 1 receptor agonists; thiazolidinediones; biguanides; sulphonylureas; dipeptidyl peptidase-4 inhibitors, insulin, amylin and others. To assess their impact, we have conducted a systematic search in PubMed to Identify studies addressing the effect of Antidiabetic treatments on AD or AD-like dementia preclinical models And clinical studies, yielding 3560 research items. After screening titl

SUBMITTER: Corraliza-Gomez M 

PROVIDER: S-EPMC12560610 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature