<i>Blastocystis</i> load mediates the gut microbiome associations with within-host diversity of <i>Blastocystis</i> in non-human primates.

ABSTRACT: Blastocystis is a prevalent gut eukaryote intricately associated with the gut microbiota. This genetically diverse protozoan exhibits significant intra-host subtype heterogeneity, yet the implications of this diversity for the host gut microbiome remain poorly understood. Here, we investigated the interactions between Blastocystis and gut microbiota in non-human primates at the level of subtypes, using a comprehensive investigation of gut microbiota for Blastocystis carriers of captive Macaca fascicularis (discovery cohort, n = 100) and Macaca mulatta (validation cohort, n = 26). We identified highly prevalent intra-host co-occurrence patterns of Blastocystis SSU rRNA-based subtypes, primarily dominated by Subtype 1 (ST1) or ST3. These patterns wer

SUBMITTER: Ma P 

PROVIDER: S-EPMC12560790 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature