Perfluorooctanesulfonic acid (PFOS) antagonizes gamma-aminobutyric acid (GABA) receptors in larval zebrafish and mammalian models.

ABSTRACT: Per- and polyfluoroalkyl substances are a class of synthetic chemicals detected ubiquitously in the environment, humans, and wildlife. Perfluorooctanesulfonic acid (PFOS) is one prevalent chemical previously shown to cause adverse effects on nervous system function across in vivo and in vitro models, including dark-phase hyperactivity in larval zebrafish. The objective of this study was to evaluate the role of gamma-aminobutyric acid receptors (GABARs), GABAAR and GABABR, as mediators of dark-phase hyperactivity in PFOS-exposed larval zebrafish. Zebrafish were acutely exposed to 7.87 to 120 μM PFOS, 0.68 to 12.4 μM picrotoxin (GABAAR antagonist), 0.77 to 14.05 μM propofol (GABAAR-positive allosteric modulator), 4.4 to 80 μM saclofen (GABABR antagonist), 0.43 to 7.87 μM CGP13501 (GABABR-pos

SUBMITTER: Owen R 

PROVIDER: S-EPMC12560803 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature