Chemical structure drives developmental toxicity of alkyl-substituted naphthalenes in zebrafish.

ABSTRACT: Naphthalene and its alkyl-substituted derivatives are among the most abundant polycyclic aromatic hydrocarbons (PAHs) in environmental and human exposure studies, yet their developmental toxicity and mode of action remain poorly understood due to challenges in testing semi-volatile compounds. This study developed a vial based, high throughput method to effectively assess the activity of naphthalenes and a set of 24 alkyl-substituted naphthalenes. Early life stage zebrafish were exposed to a concentration series of each chemical (0-50 µM) in rotating sealed glass vials to minimize volatilization. Benchmark concentration (BMC₅₀) values were calculated for morphological endpoints and lowest effect levels were determined for behavioral effects. The data were assessed for evidence of

SUBMITTER: Morshead ML 

PROVIDER: S-EPMC12560828 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature