Orosomucoid 1 Participates in Alveolar Hypercoagulation and Fibrinolytic Inhibition Involving NF-κB Signaling Pathway in LPS-Induced ARDS.

ABSTRACT: Alveolar hypercoagulation and fibrinolytic inhibition are key drivers of refractory hypoxemia in acute respiratory distress syndrome (ARDS). Orosomucoid 1 (ORM1), associated with coagulation and the NF-κB pathway, is hypothesized to regulate these processes in ARDS via NF-κB. By using LPS-induced ARDS rats and alveolar epithelial type II (AEC II) cells, we measured ORM1 expression and its effects on tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1). NF-κB pathway involvement was assessed. Clinically, bronchoalveolar lavage fluid (BALF) ORM1 levels and their correlation with TF/PAI-1 were analyzed in ARDS patients. In ARDS rats, ORM1 was upregulated in lung tissue and BALF, correlating with increased TF, PAI-1, and type III collagen. In vitro, ORM1 promoted TF and PAI-1 expre

SUBMITTER: Chen X 

PROVIDER: S-EPMC12560856 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature