Association Between Polypharmacy and Physical Function in Middle-aged Adults: Findings from the CARDIA Function Study.

ABSTRACT:

Background

Polypharmacy (≥ 5 medications) and potentially inappropriate medications (PIM; per Beers criteria) are common in midlife. Polypharmacy and PIM use are associated with poor physical function and adverse health outcomes in older age, but the associations of polypharmacy and PIM use with physical function in middle-age are poorly understood.

Objective

Estimate the associations of polypharmacy and PIM use with physical performance in middle-age.

Design

Cross-sectional analysis of the Coronary Artery Risk Development in Young Adults (CARDIA) Function study.

Participants

The CARDIA prospective cohort study enrolled 5115 participants aged 18-30 in 1985-1986. We included participants with data on self-reported medication use who completed physical performanc

SUBMITTER: Sloan CE 

PROVIDER: S-EPMC12560944 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature