An integrated multi-omic approach for discovery and dereplication of bioactive microbial natural products.

ABSTRACT: Soil bacteria are a major source of clinically useful antibiotics, yet the majority of soil-dwelling micro-organisms remain uncultivable by standard laboratory methods. To access this untapped microbial diversity, we employed microbial diffusion chambers to isolate bacteria from ten Australian soil samples. A total of 1,218 bacterial isolates were recovered, representing a diverse collection spanning 61 genera from 32 families, covering the major known phyla of soil bacteria. Antibiotic activity screening revealed that 16% of isolates inhibited the growth of at least 1 of Escherichia coli or Staphylococcus aureus, with 120 isolates displaying activity against multidrug-resistant pathogens including methicillin-resistant S. aureus and vancomycin-resistant Enterococcu

SUBMITTER: Negeri NG 

PROVIDER: S-EPMC12560952 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature