Development and Validation of a Predictive Model for Severe Tubular Atrophy/Interstitial Fibrosis in Patients with IgA Nephropathy: Multicenter Retrospective Study.

ABSTRACT:

Background

Severe tubular atrophy/interstitial fibrosis are critical pathological features associated with poor prognosis in IgA nephropathy (IgAN). The early identification of patients at high risk for severe tubular damage could guide clinical management and improve outcomes.

Objective

This study aimed to construct and validate a predictive model for assessing the risk of severe tubular atrophy and interstitial fibrosis in patients diagnosed with IgAN.

Methods

A total of 3276 patients from the Hankou branch of Tongji Hospital were retrospectively enrolled for model development. A predictive model for severe tubular atrophy/interstitial fibrosis was constructed based on independent predictors identified through univariate analysis, least absolute shrinkage and select

SUBMITTER: Yu C 

PROVIDER: S-EPMC12560959 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature