Internal Exposure to BTEX in Tropical Children: Does Exposure Speed Up Pubertal Development?

ABSTRACT: Benzene, toluene, ethylbenzene, and xylene (BTEX) are a common class of volatile organic compounds linked to adverse health outcomes. Although BTEX have been shown to have endocrine disrupting properties, their potential impacts on pubertal development in children remain unclear. In this study, for the first time, we investigated the possible association of BTEX exposure with precocious puberty (PP) and early puberty (EP) in children. We conducted a case-control study that included 246 children diagnosed with PP or EP and a controls category matched for sex and age. Urinary concentrations of seven BTEX metabolites and the oxidative DNA damage biomarker 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured by high-performance liquid chromatography-tandem mass spectrometry. Compared with the co

SUBMITTER: Lu Y 

PROVIDER: S-EPMC12561042 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature