An Immuno-Fragile Profile Is Associated with Mortality Risk in Patients with Chronic Kidney Disease.

ABSTRACT: Background/Objectives: Patients with chronic kidney disease (CKD) face higher risks of infections, poor vaccine responses, and cardiovascular diseases, leading to increased morbidity and mortality due to immune dysfunction and frailty. This study aims to evaluate immune status and frailty in CKD patients across different treatments, examine the influence of frailty on immune status, and link these factors to mortality. Methods: A total of 174 participants were included (end-stage renal disease, ESRD n = 40; hemodialysis, HD n = 40; peritoneal dialysis, n = 36; kidney transplant patients, n = 40; healthy subjects n = 18). Immunophenotyping of lymphocyte and monocyte subpopulations was performed, and frailty was assessed using the Edmonton Frail Scale. Principal component analy

SUBMITTER: Ceprian N 

PROVIDER: S-EPMC12561049 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature