Selective Targeting and Enhanced Photodynamic Inactivation of Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) by a Decacationic Vancomycin-Mesochlorin Conjugate.

ABSTRACT: Background/Objectives: Covalent conjugation of an antibiotic vancomycin (VCM) moiety and a photosensitizing mesochlorin (mChl_Pd) unit into one molecular entity may present the potential to produce the combinatorial effect of both antibacterial photodynamic therapeutic (aPDT) and antibiotic activities. Our recent study indicated that a short linkage of <4 (C-C/or C-N) bond distances between these two moieties resulted in significant steric hindrance due to the bulky VCM, which greatly reduces the accessibility of the agent to the cell surface of methicillin-resistant Staphylococcus aureus (MRSA). The observed aPDT efficacy was found to be minimal. Here, we report that the revision of this linkage, via an EG₁₀ unit using identical synthetic procedur

SUBMITTER: Yin H 

PROVIDER: S-EPMC12561113 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature