Insight into the Roles of Albumin-Alone and in Combination with Either Voriconazole or Antimicrobial Peptides Derived from Chromogranin A-In the Growth of Different Microbial Species.

ABSTRACT:

Background

Whether therapeutic albumin (ThHSA) can serve as a defense tool in Candida species (spp.) infections is still a matter of debate, although many physicians are in the habit of infusing ThHSA to restore the physiological concentration of endogenous human serum albumin (HSA). Given the need for innovative anti-Candida strategies, we assessed in vitro the role of ThHSA alone or in combination with voriconazole (VCZ) in combating Candida spp. growth and the role of bovine serum albumin (BSA)-used as a substitute for HSA-with two endogenous bovine antimicrobial peptides in combating C. albicans and other microbes.

Results

The combination of ThHSA with VCZ enhanced the antifungal effect on C. albicans, sensitive C. tropicalis, se

SUBMITTER: Schneider F 

PROVIDER: S-EPMC12561135 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature