Development and Validation of a 7-eRNA Prognostic Signature for Lung Adenocarcinoma.

ABSTRACT: Enhancer RNAs (eRNAs) are abundant in most human cells and tissues, and quantifying eRNAs has become a robust approach for biomarker discovery. While eRNAs play crucial roles in regulating biological processes and cancer progression, their functions in lung adenocarcinoma (LUAD) remain poorly understood. Here, we developed a LUAD prognostic model based on eRNA expression data from The Cancer Genome Atlas (TCGA). Through rigorous validation, a 7-eRNA signature was identified, which robustly stratified LUAD patients into high-risk and low-risk groups in both training and testing sets. Functional analyses revealed distinct enrichment of pathways related to amino acid biosynthesis, ribosome biogenesis, and proteasome activity in high-risk patients. Somatic mutation profiling highlighted TP53 a

SUBMITTER: Sun Y 

PROVIDER: S-EPMC12561158 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature