Association between small vessel disease and slow gait speed in older adults with cognitive impairment.

ABSTRACT: Subjective cognitive decline and mild cognitive impairment are often associated with gait disturbances, increasing dementia risk. Cerebral small vessel disease (CSVD) may underlie these associations.

Objective

To examine the association between CSVD lesion types and locations with slow gait speed in older adults with subjective cognitive decline and mild cognitive impairment.

Methods

In this cross-sectional study, 124 older adults met the inclusion criteria. Participants underwent clinical evaluation, gait speed assessment, and brain magnetic resonance imaging. CSVD burden was assessed using the STRIVE-2 criteria and quantified using Fazekas and modified Scheltens scales. Logistic regression analyses were conducted to calculate odds ratios (OR) with 95% confidence intervals.<

SUBMITTER: Vazquez-Guajardo M 

PROVIDER: S-EPMC12561174 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature