Molecular Design of a Naturally Derived Hemostatic Sealant with Prolonged Antimicrobial Activity for Repairing Elastic Organ Injuries.

ABSTRACT: Hemorrhaging injuries on dynamic internal organs present significant clinical burdens due to their complex nature. To address therapeutic challenges, an injectable, photocrosslinkable, and multifunctional bioadhesive hydrogel comprising methacrylated gelatin (GelMAG), methacrylated dopamine (DMA), and poly(diallyldimethylammonium chloride) (pDDA), named GDP, is engineered. The hydrogel combined underwater adhesion, antimicrobial activity, and hemostatic performance with high elasticity, biomimetic stiffness, and biocompatibility. The GDP hydrogel displayed >200% elongation and ≈50 kPa Young's modulus in tensile tests. The bioadhesive strongly adhered (>40 kPa strength) to skin, outperforming commercial sealants Coseal and Evicel, and could seal various sizes and shapes of injuries created

SUBMITTER: Jain S 

PROVIDER: S-EPMC12561306 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature