Inhibition of RNase to Attenuate Fungal-Manipulated Rhizosphere Microbiome and Diseases.

ABSTRACT: Soil-borne pathogens must cross the barriers of plant-associated microbiota to cause disease. Phytopathogens utilize effector proteins to manipulate host immunity and promote niche colonization. Identifying core effectors involved in both pathogen-microbiota and pathogen-host interactions is vital for understanding pathogenic mechanisms and designing targeted chemical compounds for disease prevention. Here, this work shows that the soil-borne pathogen Fusarium graminearum can manipulate the plant-associated rhizosphere microbiome through the virulence effector Fg12, which encodes a fungal-specific ribonuclease (RNase). Fg12 is widely distributed among various fungal pathogens, and its antibacterial function relies on RNase activity. Several Fg12-inhibited bacterial strains, both individual

SUBMITTER: Yang B 

PROVIDER: S-EPMC12561316 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature