Aptamer-Mediated Artificial Synapses for Neuromorphic Modulation of Inflammatory Signaling via Organic Electrochemical Transistor.

ABSTRACT: Artificial synaptic devices that mimic neuromorphic signal processing hold great promise for bioelectronic interfaces. However, most systems remain limited to physical stimuli or electroactive small molecules, lacking the ability to transduce biologically relevant protein signals. To address this limitation, an aptamer-mediated aqueous artificial synaptic transistor is developed capable of selectively responding to the interleukin-6 (IL-6) signal, a specifically expressed protein of inflammatory stress, via gate-voltage-induced synaptic modulation in biologically relevant electrolyte environments. Guided by molecular docking simulations, high-affinity aptamer sequences are identified for robust recognition of IL-6. The device demonstrates precise IL-6 capture and translation into neuromorp

SUBMITTER: Ding Y 

PROVIDER: S-EPMC12561412 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature