A Wearable Electrochemical Biosensor for Salivary Detection of Periodontal Inflammation Biomarkers: Molecularly Imprinted Polymer Sensor with Deep Learning Integration.

ABSTRACT: The work presented here introduces a developed electrochemical biosensor for the salivary detection of matrix metalloproteinase-8 (MMP-8), utilizing a molecularly imprinted polymer (MIP) matrix based on poly(o-phenylenediamine). To enhance detection sensitivity and modulate impedance responses, graphene oxide (GO) is incorporated as an interlayer, providing a conductive and chemically stable matrix for precise electrochemical sensing. Density functional theory simulations confirm the formation of highly selective binding sites, further reinforcing the sensor's specificity for MMP-8 detection. The impedance-based mechanism allows real-time, label-free detection of salivary MMP-8 by tracking charge transfer resistance changes via the K[Fe(CN)₆]³⁻/⁴⁻ redox probe, offering a non-inv

SUBMITTER: Jeon S 

PROVIDER: S-EPMC12561418 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature