Modelling of <i>Escherichia coli</i> Batch and Fed-Batch Processes in Semi-Defined Yeast Extract Media.

ABSTRACT: Model-based approaches provide increasingly advanced opportunities for optimizing and accelerating bioprocess development. However, to accurately capture the complexity of biotechnological processes, continuous refinement of suitable models remains essential. A crucial gap in this field has been the lack of suitable model for describing Escherichia coli growth in cultivation media containing yeast extract, while accounting for key bioprocess parameters such as biomass, substrate, acetate, and oxygen. To address this, a published mechanistic macro-kinetic model for E. coli was extended with a set of mathematical equations that describe key aspects of the uptake of yeast extract. The underlying macro-kinetic approach is based on the utilization of amino acids in E. coli,

SUBMITTER: Schroder-Kleeberg F 

PROVIDER: S-EPMC12561460 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature