Elucidating the Molecular Basis of Thermal Stress Response in Juvenile Turbot (<i>Scophthalmus maximus</i>) via an Integrative Transcriptome-Metabolome Approach.

ABSTRACT: Temperature has always been an important environmental factor, and changes in water temperature are closely related to the entire life process of fish. Investigating the impact of thermal stress on fish physiology is critical for optimizing aquaculture. This study employed transcriptomic and metabolomic approaches to investigate temperature-induced variations in the gene expression and metabolic profiles of turbot. The results showed that thermal stress could induce abnormal genes transcription, and functional annotation demonstrated predominant associations of these genes with key pathways including PI3K-Akt signaling, PPAR regulation, steroid biosynthesis, fatty acid metabolism, and FoxO signaling cascade. Metabolomic analysis revealed that amino acid metabolism was dysregulated, such as

SUBMITTER: Chen X 

PROVIDER: S-EPMC12561631 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature