Extraction Methods Shape the Phenolic Composition and Bioactivities of Defatted Moroccan <i>Pistacia lentiscus</i> L. Resin.

ABSTRACT: Mastic gum from Pistacia lentiscus L. has long been valued in Mediterranean medicine and food preservation, yet its bioactive potential remains underexplored in specific geographic contexts. In Morocco, the resin-locally known as Meska Horra-is abundant but insufficiently characterized. This study compared three extraction methods-cold maceration (CM), Soxhlet extraction (SE), and ultrasound-assisted extraction (UAE)-using sequential acetone and 70% ethanol to recover complementary phenolic compounds from defatted resin. Targeted UHPLC-ESI-MS/MS profiling identified and quantified 30 phenolics, mainly flavonoids and phenolic acids, providing the first systematic dataset for Moroccan mastic gum. UAE-EtOH extract displayed the strongest antioxidant activity (DPPH IC₅₀ = 0.0

SUBMITTER: Beraich A 

PROVIDER: S-EPMC12561634 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature