Characterization of a Novel POx-Based Adhesive Powder for Obliterating Dead Spaces After Surgery.

ABSTRACT: Surgical dead spaces are challenging to handle with current preventive methods. Tissue adhesives show promise in obliterating 'dead spaces', but the drawbacks of currently available adhesives prevent them from being used for dead space elimination. An adhesive powder based on N-Hydroxysuccinimide-poly(2-oxazoline), NHS-POx, combines robust adhesive strength in moist environments with favorable biocompatibility and biodegradability, which makes this an interesting candidate for eliminating spaces that remain between tissues after surgery. The current study evaluates the swelling, crosslinking speed, and degradation properties of this novel tissue adhesive. These results were then used to design multiple adhesive variants differing in pH, surfactant addition, and particle size, which were su

SUBMITTER: Poos SEM 

PROVIDER: S-EPMC12561639 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature