Natural Deep Eutectic Solvent (NaDES) Extraction, HPLC-DAD Analysis, and Antioxidant Activity of Chilean <i>Ugni molinae</i> Turcz. Fruits.

ABSTRACT: The demand for sustainable methods to extract bioactive compounds from native fruits is increasing. We evaluated the potential of natural deep eutectic solvents (NaDES) combined with ultrasound-assisted extraction (UAE) to recover phenolic compounds from Ugni molinae Turcz. (murta), a Chilean fruit with recognized ethnopharmacological and antioxidant value. Seven choline chloride-based NaDESs (M1-M7) were assessed and compared with conventional methanol: formic acid extraction (M8). The choline chloride: 1,2-propanediol system (1:2, M2) achieved the highest recovery of total phenolics (64.87 mg GAE/g) and flavonoids (35.38 mg QE/g), together with strong antioxidant activity (DPPH IC₅₀: 1.05 µg/mL; ORAC: 40,291 µmol TE/g). When comparing the different NaDES formulations (M

SUBMITTER: Antileo-Laurie J 

PROVIDER: S-EPMC12561733 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature