In Vivo Models of Cardiovascular Disease: <i>Drosophila melanogaster</i> as a Genetic Model of Congenital Heart Disease.

ABSTRACT: Drosophila melanogaster (D. melanogaster) has been widely used in biology, including classical genetics, for almost a century. With the entire D. melanogaster genome sequenced and the existence of transgenic and mutant individuals, the species offers opportunities for targeted gene expression and manipulation. Genes involved in the regulation of the animal's cardiac development include genes associated with the ancient regulatory networks that direct the formation of the cardiac form. However, additional loci can also affect cardiac development, including genes associated with cellular metabolism and protein homeostasis; signaling pathways necessary for the establishment of body segmentation and polarity; homeotic genes involved in the establishment of the animal body

SUBMITTER: Stougiannou TM 

PROVIDER: S-EPMC12561791 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature