Electrospun Polycaprolactone Membranes Loaded with Gentamicin and Nano-Hidroxyapatite for Guided Bone Regeneration.

ABSTRACT: Background/Objectives: Polymeric barrier membranes (BMs) are usually used in guided bone regeneration to isolate the bone defect from the surrounding tissue, favoring bone apposition. This study proposes a third-generation BM made of polycaprolactone (PCL), loaded with different concentrations of nano-hidroxyapatite (nHAP) and gentamicin (GEN), and fabricated by electrospinning. Methods: The mechanical properties of the polymer, together with the fabrication procedure, offer porosity with interconnectivity to permit cell adhesion and proliferation. Bacterial contamination of the BM can induce infection at the bone level, leading to unfavorable clinical outcomes of the regeneration procedure. Results: Therefore, BMs have been proposed as carriers for local GEN antibioti

SUBMITTER: Mirica IC 

PROVIDER: S-EPMC12561880 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature