Microalgae-Derived Peptides Targeting Lifestyle-Related Diseases: Discovery, Mechanisms, Structure-Activity Relationships, and Structural Modifications.

ABSTRACT: Microalgae are an emerging source of bioactive peptides with promising therapeutic potential against lifestyle-related diseases such as oxidative stress-related conditions, hypertension, diabetes, and obesity. While numerous studies have investigated the biological activities of microalgae-derived peptides, a comprehensive understanding of their structural features and structure-activity relationships remains limited. This review provides a detailed overview of current strategies used to discover bioactive peptides from microalgae, encompassing both conventional and computational approaches. Particular emphasis is placed on correlating identified peptide sequences with their reported biological activities to provide critical insights into the key structural motifs responsible for activity.

SUBMITTER: Qoms MS 

PROVIDER: S-EPMC12561970 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature