Multi-cellular network model predicts alterations in glomerular endothelial structure in diabetic kidney disease.

ABSTRACT: The progression of diabetic kidney disease is often characterized by early dysfunction of glomerular endothelial cells, including alterations in fenestration size and number linked to impaired glomerular filtration. However, the cellular mechanisms regulating fenestrations in glomerular endothelial cells remain poorly understood due to limitations in existing in vitro models, challenges in imaging small fenestrations in vivo, and inconsistencies between in vitro and in vivo findings. This study used a logic-based protein-protein interaction network model with normalized Hill functions for dynamics to explore how glucose-mediated signaling dysregulation impacts fenestration dynamics in glomerular endothelial cells. Key drivers of fenestration loss and size changes were identified by incorpo

SUBMITTER: Patidar K 

PROVIDER: S-EPMC12561992 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature