Comparison of Phenotypic and Whole-Genome Sequencing-Derived Antimicrobial Resistance Profiles of <i>Legionella pneumophila</i> Isolated in England and Wales from 2020 to 2023.

ABSTRACT: Background: Antimicrobial resistance (AMR) in Legionella pneumophila is emerging as a concern, particularly with resistance to macrolides and fluoroquinolones. Although clinically significant resistance in Legionella pneumophila remains uncommon, systematic genomic surveillance using whole-genome sequencing (WGS) is needed to anticipate treatment failure as metagenomic diagnostics move toward routine use. Objectives: We assessed the UK Health Security Agency AMR pipeline for predicting resistance in L. pneumophila by analysing 522 L. pneumophila isolates from England and Wales (2020-2023) together with nine database sequences that carry confirmed 23S rRNA mutations conferring high-level azithromycin resistance. The objective of the present study wa

SUBMITTER: Tewolde R 

PROVIDER: S-EPMC12562041 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature