Edaravone Mitigates Postovulatory Aging by Preserving Oocyte and Embryo Quality in Mice.

ABSTRACT: Postovulatory aging (POA) significantly contributes to fertility decline, primarily through oxidative stress, which impairs oocyte quality, reduces embryonic developmental competence, and may adversely affect offspring health. Edaravone (EDA), a potent free radical scavenger, is known for its cytoprotective effects in various disease models. This study aimed to evaluate whether EDA can mitigate the detrimental effects of POA on mouse oocyte and embryo quality and confirm its reproductive safety. Supplementation with 10 nM EDA significantly reduced meiotic abnormalities, restored mitochondrial distribution, enhanced mitochondrial membrane potential and ATP production, and decreased intracellular reactive oxygen species (ROS) in aged oocytes. Although EDA did not markedly improve fertilizati

SUBMITTER: Kim KH 

PROVIDER: S-EPMC12562146 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature