The Role of the Cell Surface Heparan Sulfate Proteoglycan Syndecan-3 in Breast Cancer Pathophysiology.

ABSTRACT: The heparan sulfate proteoglycan syndecan-3 (SDC3) is a critical regulator of cell-matrix interactions. While other syndecan family members contribute to the progression of multiple cancers, SDC3's functional contributions to tumor biology remain largely unexplored. This study investigates the potential role of SDC3 in the pathogenesis of breast cancer. By conducting an in-silico analysis of publicly available datasets, including TNM-plot, The Human Protein Atlas, and Kaplan-Meier Plotter, we observed that SDC3 is upregulated in breast cancer tissue. Notably, high SDC3 expression correlates with improved relapse-free survival in breast cancer patients. In vitro experiments revealed that SDC3 depletion significantly impairs cell viability, cell-cycle progression, cell m

SUBMITTER: Habenicht L 

PROVIDER: S-EPMC12562340 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature