Facile Synthesis of <i>N</i>-vinylindoles via Knoevenagel Condensation: Molecular Features and Biological Activities.

ABSTRACT: N-vinylindoles have attracted attention for their promising role in medicinal chemistry. Therefore, developing new synthetic methods that enable access to diverse functionalized N-vinylindoles with potential pharmacological properties is highly valuable. 1-[2-aryl-1-(4,5-dihydro-1H-imidazol-2-yl)vinyl]-1H-indoles 2a-i were prepared via Knoevenagel condensation promoted by 1H-benzotriazole, and characterized by IR, NMR, and MS spectroscopic data as well as a single-crystal X-ray diffraction-based study of the representative derivative 2g. The obtained compounds 2a-i were screened for their cytotoxic potency against human cancer cell lines (HeLa, SKOV-3, AGS) and non-cancerous cell line (HaCaT) using the MTT assay. Additio

SUBMITTER: Kornicka A 

PROVIDER: S-EPMC12562379 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature