Development and Characterization of Topical Gels Containing Lipid Nanosystems Loaded with <i>Echinacea purpurea</i>.

ABSTRACT: This study explores an innovative delivery strategy for the management of skin conditions: lipid nanosystems incorporated into a gel matrix. Echinacea purpurea extract, known for its antibacterial, antioxidant, and wound-healing properties, was encapsulated into lipid-based nanosystems and subsequently incorporated into Carbopol-based gel. The extract, rich in chicoric and caftaric acids, exhibited strong antioxidant activity (IC₅₀ = 56.9 µg/mL). The resulting nanosystems showed nanometric size (about 200 nm), high entrapment efficiency (63.10-75.15%), and excellent short-term stability. Superior biocompatibility of the nanosystems, compared to the free extract, was demonstrated using an MTS assay on L-929 fibroblasts. Moreover, the cytoprotective potential of the lipid c

SUBMITTER: Pavaloiu RD 

PROVIDER: S-EPMC12562447 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature