MoS₂ Nanoflower-Based Colorimetric and Photothermal Dual-Mode Lateral Flow Immunoassay for Highly Sensitive Detection of Pathogens.

ABSTRACT: The single colorimetric signal readout mode of traditional lateral flow immunoassay (LFIA), which relies on gold nanoparticles (Au NPs), is inadequate to meet the growing demand for detection in terms of sensitivity, accuracy, and flexibility. Herein, we reported a novel colorimetric and photothermal dual-mode LFIA (dLFIA) based on MoS₂ nanoflowers for rapid detection of severe acute respiratory syndrome coronavirus 2 nucleocapsid protein (SARS-CoV-2 NP). Benefiting from the strong color-producing ability and near-infrared absorption of MoS₂ nanoflowers, the visual limits of detection in colorimetric and photothermal modes were 1 and 0.1 ng/mL, respectively. The limit of detection for quantitative analysis in photothermal mode was 48 pg/mL, with a sensitivity about 10

SUBMITTER: Xu M 

PROVIDER: S-EPMC12562453 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature