Synaptic Plasticity-Enhancing and Cognitive-Improving Effects of Standardized Ethanol Extract of <i>Perilla frutescens</i> var. <i>acuta</i> in a Scopolamine-Induced Mouse Model.

ABSTRACT: In our previous study, we demonstrated that a standardized ethanol extract of Perilla frutescens var. acuta (PE) alleviates memory deficits in an Alzheimer's disease mouse model by inhibiting amyloid β (Aβ) aggregation and promoting its disaggregation. However, the extent to which PE exerts additional cognitive benefits independent of Aβ pathology remained unclear. Here, we aimed to evaluate the effects of PE on synaptic plasticity and learning and memory functions. Male ICR mice were used, and cognitive impairment was induced by scopolamine administration. PE was orally administered at doses determined from previous studies, and cognitive performance was assessed using the passive avoidance, Y-maze, and Morris water maze tests. In parallel, hippocampal slices were employed t

SUBMITTER: Lee J 

PROVIDER: S-EPMC12562524 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature