Inhibitory Effect of <i>Boesenbergia rotunda</i> and Its Major Flavonoids, Pinostrobin and Pinocembrin on Carbohydrate Digestive Enzymes and Intestinal Glucose Transport in Caco-2 Cells.

ABSTRACT: Boesenbergia rotunda (L.) Mansf., commonly known as fingerroot or "Kra-Chai," is a traditional Thai medicinal plant used for treating digestive and metabolic disorders. Recent evidence highlights its potential role in controlling hyperglycemia, though its active compounds and mechanisms remain unclear. This study evaluated the antidiabetic activity of B. rotunda crude extract and its major flavonoids, pinostrobin and pinocembrin, through in vitro enzyme inhibition and cellular glucose transport assays. Pinocembrin exhibited the strongest inhibition of both α-amylase and α-glucosidase, while pinostrobin and the crude extract showed moderate effects. In Caco-2 cells, the crude extract reduced glucose uptake, whereas both flavonoids markedly inhibited transport under glucose-dep

SUBMITTER: Aimjongjun S 

PROVIDER: S-EPMC12562543 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature