Factors Influencing the Colostrum's Microbiota: A Systematic Review of the Literature.

ABSTRACT: Background/Objectives: Human colostrum plays a crucial role in early microbial colonization, immune development, and gut health of newborns. Its microbiota is highly dynamic and influenced by numerous factors, yet the determinants remain poorly understood. This systematic review aims to investigate the composition of colostrum microbiota and the intrinsic and extrinsic factors that influence its diversity and abundance. Methods: PubMed and Scopus were systematically searched using a prespecified search phrase. Data on microbial composition, diversity, and influencing factors were extracted and analyzed. The systematic review is registered in PROSPERO (CRD42025644017). Results: A total of 44 eligible studies involving 1982 colostrum samples were identified. Colostrum mi

SUBMITTER: Tzani A 

PROVIDER: S-EPMC12562569 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature