Inulin aggravates colitis through gut microbiota modulation and MyD88/IL-18 signaling.

ABSTRACT: Different types of dietary fibers exert distinct effects on gut microbiota and overall health, playing a complex role in disease-specific contexts. Here, we found that while supplementation with dietary soluble fiber inulin does not induce inflammation under steady-state conditions, it exacerbates intestinal inflammation in a DSS-induced colitis mouse model in a gut microbiota-dependent manner. Mechanistically, we found that inulin consumption increases the overall bacterial load with expansion of pro-colitis pathobiont, elevates levels of pro-inflammatory component flagellin, and reduces microbial diversity. These microbiota changes drove colitis aggravation via GR-1⁺ cell-mediated inflammation. Using NLRC4/TLR5- and MyD88-deficient mice, we identified microbiota-derived pro-inflammatory

SUBMITTER: Zhao X 

PROVIDER: S-EPMC12562683 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature